Researchers at the University of North Carolina (UNC) School of Medicine have found a new target for treating chronic pain: an enzyme called PIP5K1C. In a paper published May 21 in the journal Neuron, a team of researchers led by Mark Zylka, PhD, Associate Professor of Cell Biology and Physiology, shows that PIP5K1C controls the activity of cellular receptors that signal pain. By reducing the level of the enzyme, researchers showed that the levels of a crucial lipid called PIP2in pain-sensing neurons is also lessened, thus decreasing pain.
New therapy for chronic pain
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